phenotypic characterization of complement factor h r1210c rare genetic variant in age-related macular degeneration

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Answer 1

Phenotypic characterization of complement factor h r1210c rare genetic variant in age-related macular degeneration. This is a correct statement.

What is a complement factor?

Due to its capacity to destroy activated complement proteins, C3b and C4b in the presence of cofactors such as factor H, C4b-binding protein, complement receptor 1, or CD46, factor I (FI) is an essential inhibitor governing all complement pathways.

Rare complete FI deficiency results in complement consumption, which fuels recurring severe infections, glomerulonephritis, or autoimmune disorders. FI is mostly produced in the liver. A typical hemolytic uremic syndrome, a serious illness marked by thrombocytopenia, microangiopathic hemolytic anemia, and abrupt renal failure, is in turn linked to incomplete FI deficiency.

Therefore the statement is correct.

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Related Questions

disadvantage of organic fertilizer​

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Answer:

See below.

Explanation:

Organic fertilizer is more environmentally friendly and economical, but it comes at a different cost. These fertilizers are both harder to obtain and take more effort to formulate. Furthermore, these products are not created equally, meaning some of them may not work as well and have inconsistencies. Correspondingly, they are also lower in nutrients, meaning crops that rely on fertilizer will not grow as effectively and risk dying.

The sickle-cell allele most likely originated when a mutation occurred in a normal hemoglobin allele. If the trait arose in africa, where did it most likely originate?.

Answers

The mutation for sickle cell allele most likely originated in Congo (near Kinshasa).

Mutation refers to the change in nucleotide sequence of DNA during cell division in an organism. It can be beneficial or harmful for a population. Mutations for sickle cell allele were originated in Congo by altering a normal haemoglobin allele.

The mutation for the sickle cell allele originated in Congo near Kinshasa and provided a better chance of survival to heterozygous individuals for this allele. As this mutant allele was transferred to the next generations, it allowed them to survive and reproduce with better success and spread the mutation among the populations through migration.

This can be considered an example of natural selection where heterozygous individuals for sickle cell alleles had better chances of survival and reproduction. The heterozygous individuals with sickle cell allele exhibit resistance to malaria. When such individuals get affected by the malarial parasite, their RBCs tend to turn sickle and defend against malaria.

The sickle-cell allele most likely originated when a mutation occurred in a normal hemoglobin allele. If the trait arose in Africa, it most likely originated in Congo.

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Which of the following best describes prokaryotes and eukaryotes?

Prokaryotes have a nucleus and eukaryotes do not.
Prokaryotes do not have a nucleus; eukaryotes have a nucleus.
Both have membrane-bound structures.
Prokaryotes have membrane-bound structures and eukaryotes have free floating organelles.

Answers

Answer:

Prokaryotes do not have a nucleus; eukaryotes have a nucleus.

Explanation:

The generic material of a prokaryotic cell is not in organized form as in eukaryotic cells. They are found in a region called nucleiod or genophore. They also lack membrane bound organelles. Ribosomes are found in both.

Answer:

Prokaryotes do not have a nucleus; eukaryotes have a nucleus.

Explanation:

What result would Jost have obtained if female development also required a signal from the gonad?

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The result Jost has obtained if female development also required a signal from the gonad is that the female genitalia was reliant upon the signs from embryonic gonadal cells.

In females, the ovaries (one of the interior genitalia) are the gonads, while on account of males, the testicles (one of the outer genitalia) are the gonads.

The exploratory investigation of Jost proposed that signs from the embryonic male gonad cells are fundamental for the arrangement of male genitalia, and the shortfall of these signs brought about the development of female genitalia.

The development of female genitalia was reliant upon the hormonal signs of the female embryonic testicle. Then, at that point, it would have been seen that none of the exploratory incipient organisms (in which the medical procedure of gonadal cell has been performed) would grow fundamentally or practically typical genitalia.

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The rattlesnake alerts enemies to its presence with a rattle-a set of modified scales at the tip of its tail. Describe the distinct roles of gated ion channels in initiating and moving a signal along the nerve from the snake's head to its tail and then from that nerve to the muscle that shakes the rattle.

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Neurotransmitters activate gated ion channels, which allow molecules (Na+ and K+) to diffuse information and leave the axon. This generates the membrane potential, which depolarizes the axon and sends a signal until it reaches and activates the muscle.

What are Neurotransmitters?

Neurotransmitters are chemical messengers that travel throughout the body. Their function is to send signals from nerve cells to target cells.

These target cells could be found in muscles, glands, or nerves. The nervous system contains neurotransmitters.

Gated ion channels is opened by neurotransmitters, allowing molecules (Na+ and K+) to diffuse and exit the axon.

The membrane potential is generated, which depolarizes the axon as well as transmits a signal till it attains and activates the muscle.

Thus, this is the distinct roles of gated ion channels in initiating and moving a signal.

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What happens to the alcohol in a bulb thermometer as the temperature decreases?

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Answer:

What happens to the alcohol in a bulb thermometer as the temperature decreases? As the alcohol cools down, the kinetic energy of the alcohol particles declines. When the alcohol particles move less, they move closer together, and the alcohol contracts.

Explanation:

Describe the relationship between pH and acidity. (See Concept 3.3.) Overall, is the precipitation in this forest becoming more acidic or less acidic?

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Acid rain has a pH of approximately 4.3 because of the elements present. The precipitation in the given forest is becoming more acidic since the pH is 4.0.

A pH scale is used to assess acidity and alkalinity, with 7.0 representing neutrality. A substance's pH scales from 0 to 14, with 0 being the most acidic and greater than 7 being alkaline. A regular rain has a pH of around 5.6, making it mildly acidic due to the dissolution of carbon dioxide (CO2) into water to create weak carbonic acid. The pH of acid rain typically ranges from 4.2 to 4.4.

Any type of precipitation that contains acidic elements, such as sulfuric or nitric acid, that falls to the ground in wet or dry forms from the atmosphere is referred to as acid rain, also known as acid deposition. This can apply to rain, snow, fog, hail, and even corrosive dust.

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______ are released from axon terminals and are detected by protein receptors on an adjacent neuron.

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Neurotransmitters are released from axon terminals and are detected by protein receptors on an adjacent neuron.

At a chemical synapse, one neuron releases neurotransmitter molecules right into a small area that is adjoining to every other neuron. The neurotransmitters are contained inside small sacs known as synaptic vesicles and are launched into the synaptic cleft with the aid of exocytosis.

Neurotransmitters are launched from synaptic vesicles in presynaptic neurons in response to neural activity, diffuse across the synaptic cleft, and bind unique receptors if you want to result in modifications in postsynaptic neurons.

Neuronconnect with other cells inside the frame including different neurons, muscle cells, and organs. those connections arise at junctions known as synapses. The synapses allow electrical and chemical messages to be transmitted from the neuron to the alternative cells in the body.

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Water leaving a reservoir behind a dam is often taken from deep layers of the reservoir. Would you expect fish found in a river below a dam in summer to be species that prefer colder or warmer water than fish found in an undammed river? Explain.

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Fish that like colder water are more likely to be found in rivers that are below dams.

How do dams impact the number of fish?The construction of a dam on a river can obstruct or delay upstream fish migration, which has the effect of reducing or even eradicating species that depend on longitudinal migrations along the stream continuum at particular times of their life cycles. Dams can provide energy, maintain the security of water, and protect against flooding, but they also pose a major threat to freshwater species. Dams alter fish life cycles and lower their reproductive potential by obstructing their ability to travel along natural routes between spawning and feeding grounds. Rivers below dams are more likely to have fish that prefer colder water.

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In the deserts of the southwestern United States, the soils are mostly sandy, with occasional large regions of black rock derived from lava flows that occurred 1.7 million years ago. Mice are found in both sandy and rocky areas, and owls are known predators. What might you expect about coat color in these two mouse populations? Explain. How would you use this ecosystem to further test the camouflage hypothesis?

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In the deserts of the southwestern United States, the soils are mostly sandy, with occasional large regions of black rock derived from lava flows that occurred 1.7 million years ago. Mice are found in both sandy and rocky areas, and owls are known predators.

What might you expect about coat color in these two mouse populations? Explain.

How would you use this ecosystem to further test the camouflage hypothesis?

Based on the coloration of the mice, you might expect mice that live on sandy soil to be lighter and those that live on lava rock to be much darker. And in fact, scientists have found and predict that each color of mouse would be less hunted in its natural environment than in another environment. You can repeat Hoekstra's experiment with colored models painted to resemble these two types of mice. Or you could try transplanting a portion of each population into its non-native habitat rather than a different habitat. In a live mouse transplant experiment, you would have to make controls to remove the variable introduced by the transplanted mice in new, unfamiliar territory. You could control the transplant process by transplanting some dark mice from one lava rock area to a distant one, and some light mice from one sandy soil area to a distant area.

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Most of the soil in the southwestern United States' deserts is sandy, however there are occasionally sizable areas of black rock made of lava flows that happened 1.7 million years ago. Both rocky and sandy environments contain mice, and owls are well-known mice hunters.

How would you utilise this environment to expand on the notion of camouflage?You may anticipate that mice living on lava rock would be lot darker and those living on sandy soil would be much lighter based on the colours of the mice.In actuality, scientists have discovered and predicted that each colour of mouse will be pursued less frequently in its native environment than in another area.Hoekstra's experiment may be repeated using coloured models that have been painted to mimic these two varieties of mouse.You would need to create controls in a live mouse transplant experiment to eliminate the variable that the transplanted mice introduced in their new environment.

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many proteins are secreted from the cell following the process of translation. list two organelles involved in protein secretion, and briefly explain their contributions.

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many proteins are secreted from the cell following the process of translation.the two organelles involved in protein secretion and their contribution are  The rough endoplasmic reticulum modifies the proteins. The Golgi apparatus is involved in sorting, modifying, and packaging proteins. Vesicles transport the proteins to the plasma membrane and release them from the cell.

The endoplasmic reticulum is, in essence, the transportation system of the eukaryotic cell, and has many other important functions such as protein folding. It is a type of organelle made up of two subunits – rough endoplasmic reticulum, and smooth endoplasmic reticulum.here the Golgi apparatus, also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination.

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An individual is hospitalized due to complications from copd and pneumonia. the antibiotics administered resulted in acute renal failure. what abg result is possible?

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The ABG result would be the renal failure build up metabolic acidosis

How does arterial blood gas work?

One of the examinations used to identify COPD is an arterial blood gas test. The test determines your blood's oxygen content (O2) as well as how well carbon dioxide (CO2) is expelled. Your blood's pH can also be calculated using this method. It is possible to assess respiratory conditions, kidney function, and the body's metabolism by measuring imbalances in the levels of oxygen, carbon dioxide, or pH. (the process by which our body converts food into energy that can be used right away or stored in the liver, muscles and body fat).

The buildup of acid inin the body due to kidney disease or kidney failure called metabolic acidosis.

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Who is credited with being the father of the modern u. S. Wilderness conservation?.

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Gifford Pinchot, the founding director of the U.S. Forest Service, was born on Saturday. He is referred to as the "father of conservation" and is credited with starting the conservation movement in the US by persuading people to protect the future by preserving the past.

The Sierra Club was founded by American naturalist John Muir (1838–1914), who is regarded as the grand father of conservation. He pushed to establish Yosemite National Park and protect the Sierra Nevada in California. Leopold joined the U.S. Forest Service after graduating from Yale and was placed in the Arizona Territories. During his time in office.

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Careful analysis of many types of organisms suggests that the amazingly complex camera-like eyes of vertebrates and cephalopod molluscs (octopuses and squids) formed through _______

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Careful analysis of many types of organisms suggests that the amazingly complex camera-like eyes of vertebrates and cephalopod molluscs (octopuses and squids) formed through gradual refinement that occurred in both molluscs and vertebrates lineage to produce camera like structure in both molluscs and vertebrates.

The modern style of camera style eye of the vertebrate have evolved roughly 500 million years ago. The basic pattern of eyes are same in all vertebrates which is spherical structure fitted with cornea for passing light. It is complex structure consisting of retina, iris, ciliary body, optic nerves, etc.

Cephalopods are active marine predators which also have camera type structure which is very complex.

The similar eye structure in vertebrates and cephalopods are convergent in structure.

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explain how high specific heat and expansion upon freezing sustain life

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Life forms can keep relatively consistent interior temperatures because water has a high specific heat that makes them resistant to temperature changes. Water has a high boiling point due to its high specific heat and surface tension, which helps maintain its liquid for the majority of biological processes. Expansion upon freezing sustains life because Ice takes up more area than water because it expands (it is less dense). As a result, the ice floats on the water.

The specific heat capacity of a substance, also known as the massic heat capacity, is the heat capacity of a sample of the substance divided by the mass of the sample. Due to the thermal energy released by chemical processes within cells, specific heat aids in preventing organisms from overheating. When the outside temperature changes or rises, it aids organisms in maintaining a comparatively constant internal temperature.

Water crystallizes into an open hexagonal structure when it freezes, which accounts for the expansion that occurs. More room is there in this hexagonal lattice than in the liquid state. When water is cooled to a temperature of about 4 degrees Celsius, it begins to constrict as one would expect. It then gradually grows until it reaches the freezing point, at which point it freezes and expands by around 9%.

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Explain how prokaryotes, though small, can be considered giants in their collective impact on Earth and its life.

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Prokaryotes can be considered giants in their collective impact on Earth and its life because they play key roles as decomposers.

What is the ecological role of prokaryotic organisms?

The ecological role of prokaryotic organisms is fundamental to maintaining diversity levels in nature by allowing the carbon cycle as decomposers of dead higher organisms.

In conclusion, Prokaryotes can be considered giants in their collective impact on Earth and its life because they represent the major part of biomass and play key roles as decomposers.

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Betty's metabolism has been irregular and she has been moody, tired, and weak. there is most likely an abnormality with her _____ gland.

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According to the research, the correct option is thyroid. Betty's metabolism has been irregular and she has been moody, tired, and weak. There is most likely an abnormality with her thyroid gland.

What is thyroid gland?

It is an organ located in the anterior region of the neck formed by two bilateral lobes and is responsible for producing hormones and regulating the body's sensitivity to them.

In this sense, it is responsible for multiple functions, among the main ones giving energy to the body, regulating metabolism, when there is an abnormality in this, problems of nervousness, muscle cramps, fatigue, weight loss, irritability, bowel movements usually occur.

Therefore, we can conclude that according to the research, the correct option is thyroid. Betty's metabolism has been irregular and she has been moody, tired, and weak. There is most likely an abnormality with her thyroid gland.

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A tough layer of vascular connective tissue, called the ______________________, covers the bone and is continuous with ligaments and tendons.

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A tough layer of vascular connective tissue, called the Periosteum, covers the bone and is continuous with ligaments and tendons.

What is vascular connective tissue?

It is a type of tissue that is accountable for the transportation in the animal's body. It is also anointed fluid connective tissue. It maintains continuity in the animal body by combining different parts of the body. It has two kinds, and they are blood and lymph.

What is an representative of vascular connective tissue?

Blood: It is a sticky, thick, and saltish vascular connective tissue. It is also named red vascular connective tissue because it is red-colored. It consists of two components that are blood cells and blood plasma.

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The glands that are saclike in structure and produce oily secretions that lubricate the skin are?

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The glands that are saclike in structure and produce oily secretions that lubricate the skin are sebaceous glands.

Glands are the organs present in the body that produce and secrete some chemical substances. These chemical substances are necessary for various processes in the body. Glands can be of two types: Endocrine, which releases secretions directly into the blood and exocrine, that release secretions into some duct or opening.

Sebaceous glands are the exocrine gland that secrete a substance called sebum. Sebum is an soil, wax-like substance that functions to lubricate the hair and skin. The gland opens into the root of hair follicle and is present only in mammals. The maximum sebaceous glands are found in the scalp.

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Where are chromosomes that contain dna found? inside a person’s genes on the outside of a gamete in the nucleus of a cell around the double helix structure

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The chromosomes that contain DNA are found inside the cell nucleus (in eukaryotic organisms).

What are chromosomes?

The chromosomes can be defined as linear fragments of DNA of an organism that contain specific sequences of nucleotides that determine gene sequences and they are found within the cell nucleus.

Chromosomes are fragments of the genome, they are located in the cell nucleus where transcription of genes and subsequent use of these transcripts (mRNAs) during translation leads to the production of proteins.

In conclusion, the chromosomes that contain DNA are found inside the cell nucleus (in eukaryotic organisms).

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Answer:

nucleus

Explanation:

cause i said

briefly explain how an endonuclease (like cas9) compares to a restriction enzyme (like haeiii or bcli). what is a similarity? what is a difference?

Answers

In comparison , Cas9 is an endonuclease and is developed as an immunity mechanism against viruses, which  are not considered restriction enzymes.

Talking about the similariites and differences, endonuclease is an enzyme by cleaving the internal covalent bonds linking nucleotides to break down a nucleotide chain into shorter chains, whereas the restriction enzyme, considered the restriction endonuclease can cleave DNA molecules into small pieces. Cas9 is an endo-deoxyribonuclease, it trims the DNA a little bit, from the cut site, one of the differences is that to identify the target sites in the DNA restriction enzymes doesn't have an RNA or a DNA as a tether. They can recognize the restriction sites by themselves through their DNA binding domains. Compare to restriction enzymes, the endonuclease can't cleave any DNA complementary to the guide RNA, they need the help of protospacer adjacent motifs adjacent sequences to the target site. The cleaving process occurs at a specific site called the restriction site, of the  DNA molecule,  where the site is composed of  4 to 8 base pairs. The restriction enzyme is all about all in one system whereas the endonuclease enzyme recognizes first and cleaves the latter, within a  specific nucleotide sequence.

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Why do so many substances dissolve in water?
O It can completely surround individual molecules.
O It's a polar substance with positive and negative charges.
O It contains enzymes that break down other substances.
O Water molecules readily bond to other substances.

Answers

Answer:

Its a polar substance with positive and negative charges.

Explanation:

Because of its polarity and ability to form hydrogen bonds.

a person appears to have an infected toe. a sample of pus is taken from the toe and examined under a microscope, but no evidence of any kind of cell can be found. what could be causing the infection?

Answers

Upon examining the pus from the infected toe, when no evidence of any kinds of cell is found, it can be concluded that the causative microbe is virus.

Pus is a thick, yellow-whitish fluid that can be seen to be accumulated at the site of infection. It is actually the dead white blood cells' debris that accumulate to fight the infection and protect the body from further infection.

Virus are the acellular creatures. These are considered to be living when present inside any living organism. They do not exhibit any properties of a cell, hence are called acellular. This is the reason why virus could be the causing organism for the disease when no cellular organism was found.  

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What invention/process of the industrial revolutions has had the most amplification of anthropogenic impacts on the planet?

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The invention/process of the industrial revolutions that had the most amplification of anthropogenic impacts on the planet was that some economists say the major impact was the standard of living for the general population began to increase consistently.

What is Revolution?

The Industrial Revolution was the shift to new industrial techniques that took place in Great Britain, continental Europe, and the United States between roughly 1760 and 1820–1840.

The first three industrial revolutions that had an impact on our contemporary civilization are listed above. The steam engine, the age of science and mass production, and the rise of digital technology were three innovations that dramatically altered the world as we knew it.

Therefore, the process of the industrial revolutions that had the most amplification of anthropogenic impacts on the planet was that some economists say the major impact was the standard of living for the general population began to increase consistently.

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A doctor might give bicarbonate HCO³⁻ to a patient who is breathing very rapidly. What is the doctor assuming about the patient's blood chemistry?

Answers

Since the blood is thought to have grown acidic, the patient is given bicarbonate by the doctor.

The pH scale goes from 0 to 14, and it indicates how basic or acidic a solution or mixture is. A pH of 7 or greater is neutral, whereas a pH of 7 or less is acidic.Blood often has a simple flavor. The blood can occasionally produce too much acid, though. Acidosis is the medical term for this. Respiratory acidosis is a particular kind of acidosis. When the respiratory system, more specifically the lungs, fail to evacuate carbon dioxide, respiratory acidosis results. This may be related to a lung condition that makes it difficult to expel carbon dioxide. The blood in particular will have a lower pH due to the excess carbon dioxide in the body. When a person consumes anything that, when broken down, produces acids, it might result in metabolic acidosis.The person's breathing becomes fast due to the presence of acid in the blood. A buffer is introduced when the patient is given bicarbonate. Since bicarbonate is basic, it will aid in neutralizing or balancing the blood's acidity and preventing future issues.

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How do imprinting in geese and song development in sparrows differ with regard to the resulting behavior?

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For the goose, all that is acquired is an object at which the behavior is directed. In the case of the sparrow, learning takes place that will give shape to the behavior itself.

What is imprinting ?

In psychobiology, imprinting is a type of learning in which a very young animal focuses its attention on the first thing it sees, hears, or touches and then proceeds to pursue that object.

Imprinting helps baby birds visually identify with other members of their species so they can make the right mating decisions later in life. It also enables baby birds to understand the proper behaviours and vocalisations for their species.

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Which structure acts like an invisibility cloak and protects bacteria from being phagocytized?.

Answers

Capsule structure acts like an invisibility cloak and protects bacteria from being phagocytized.

What is the composition of capsule?

From bacterium to bacteria, the content of the capsule varies. Capsules include 98% water and 2% polysaccharide. Capsules are primarily made of polysaccharide. The lengthy strands of carbohydrates are called polysaccharides. Long carbohydrate chains are created by combining monomeric subunits. Different monomeric units bind to each other through glycosidic connections. They yield the monomeric elements that make up the polysaccharide unit upon hydrolysis.

Glycoproteins are a component of several bacterial capsules. The structure of glycoproteins is where the carbohydrate group is joined to the amino acids of proteins. Covalent bonds between carbohydrate groups and the polypeptide chain allow for attachment.

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The peritoneal cavity is located between the visceral peritoneum and the mesentery. True or false

Answers

The peritoneal cavity is located between the visceral peritoneum and the parietal peritoneum. So the statement is false.

What is the peritoneal cavity?

The peritoneum is a serous membrane that covers the abdominal and pelvic organs and borders the walls of the abdominal cavity. The peritoneal cavity lies between its parietal and visceral layers. Abdominopelvic organs are supported and shielded by the peritoneum.

There are two layers to the peritoneum:

An external layer that is attached to the front and posterior abdominal walls is called the parietal peritoneum.A layer that lines the internal organs of the abdomen is called the visceral peritoneum. It is created when the parietal peritoneum rebounds from the viscera to the abdominal wall.

Therefore the statement is false.

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According to anthropology, if humanity cannot be divided into a series of genetically distinct units, then?

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According to anthropology, if humanity cannot be divided into a series of genetically distinct units, then the concept of human race will be biologically meaningless.

According, to the concept of human race that give the idea of the human species and said that human species is divided into distinct groups on the basis of the inherited physical and behavioral differences.

Their are 4 major races present in the world's population, that are white/caucasian, mongoloid/asian, negroid/black, and australoid. This racial classification was suggested by carleton S.

The human race was invented by european naturalists and anthropologists.  The human race was initiated from the homo habilis, or handy mam.

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a neuron with an excitatory center-inhibitory surround receptive field will respond most when we stimulate .​

Answers

A neuron with an excitatory center-inhibitory surround receptive field will respond most when we stimulate only the center. Stimulating middle and surround regions concurrently decreases responding of the neuron, as compared to stimulating the excitatory location alone. A receptive discipline that includes a more or less round excitatory location surrounded with the aid of using an inhibitory location, or a round inhibitory middle surrounded with the aid of using an excitatory surround.

Center-surround receptive discipline - receptive discipline wherein the middle of the receptive discipline responds otherwise to stimulation than the encircling part of the discipline.

There are  number one forms of ganglion mobileular receptive fields: ON middle/OFF surround mobileular: Flashing small vibrant spot withinside the middle subregion will increase the mobileular's response. Flashing a vibrant annulus withinside the surround subregion inhibits the mobileular's response.

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